Répertoire du corps professoral

Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines
Programme: Regroupements stratégiques NT
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Nature et technologies
Type de financement: Subvention
Établissement tête: Université du Québec à Montréal - UQAM
Du 1 avril 2024 au 31 mars 2030

Biologics RAMP-UP: Biologics Rapid Actuation of Mass Production Under Pandemic conditions
Programme: Fonds de recherche biomédical du Canada (FRBC)
Organisme(s) subventionnaire(s): Secrétariat des programmes interorganismes à l’intention des établissements
Type de financement: Subvention
Établissement tête: École polytechnique de Montréal
Du 1 mars 2024 au 31 mars 2028

Biologics RAMP-UP: Biologics Rapid Actuation of Mass Production Under Pandemic conditions
Programme: Fonds d'infrastructure de recherche en sciences biologiques (FIRSB)
Organisme(s) subventionnaire(s): Ministère de l'Économie et de l'Innovation, Fondation Canadienne pour l'innovation (La)
Type de financement: Subvention
Établissement tête: École polytechnique de Montréal
Du 1 mars 2024 au 31 mars 2028

Repousser les frontières de l'étude de la biologie à l'échelle nanométrique en conditions naturelles
Programme: Fonds d'innovation (FI)
Organisme(s) subventionnaire(s): Fondation Canadienne pour l'innovation (La), CIUSSS-CN CERVO, Ministère de l'Économie et de l'Innovation et de l'énergie, Ministère de la Santé et des Services sociaux
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2023 au 31 mars 2025

Canada Research Chair in Synthetic Biology and Systems Biomedicine
Programme: Chaires de recherche du Canada - Fonctionnement
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mai 2023 au 29 avril 2028

The role of conformational dynamics in viral fusion proteins epitopes presentation and recognition for antibody engineering applications
Programme: Subventions à la découverte SD (individuelles et d'équipe)
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2023 au 31 mars 2028

Chaire de Recherche du Canada en Biologie Synthétique et Biomédecine des Systèmes
Programme: Fonds des leaders John-R.-Evans (FLJR)
Organisme(s) subventionnaire(s): Ministère de l'Économie et de l'Innovation, Fondation Canadienne pour l'innovation (La)
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2023 au 31 décembre 2024

Financements des 2 dernières années

Forum des nouveaux chercheurs de l'IMII des IRSC
Programme: Forum des nouveaux chercheurs de LIMII des IRSC
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 mars 2024 au 31 mars 2024

The role of conformational dynamics in viral fusion proteins epitopes presentation and recognition for antibody engineering applications
Programme: Supplément Tremplin vers la découverte
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2023 au 31 mars 2024

Cryo-TEM infrastructure for the visualisation of nanoparticles, exosomes and virus-like particles
Programme: Subventions d'outils et d'instruments de recherche (OIR)
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 31 mars 2023 au 31 mars 2024

Sabrina Gentil, Doctorat en biochimie

Christophe Dussault, Maîtrise en biochimie - avec mémoire

Hyerin Kim, Maîtrise en biochimie - avec mémoire

Jacob Côté,

Publications des 5 dernières années

SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition bioRxiv, 2024. Zhang, Q.E., Lindenberger, J., Parsons, R.J., Thakur, B., Parks, R., Park, C.S., Huang, X., Sammour, S., Janowska, K., Spence, T.N., Edwards, R.J., Martin, M., Williams, W.B., Gobeil, S., Montefiori, D.C., Korber, B., Saunders, K., Haynes, B.F., Henderson, R., Acharya, P.. DOI 10.1101/2024.02.12.580004

SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition Molecular Cell, 2024. Zhang, Q.E., Lindenberger, J., Parsons, R.J., Thakur, B., Parks, R., Park, C.S., Huang, X., Sammour, S., Janowska, K., Spence, T.N., Edwards, R.J., Martin, M., Williams, W.B., Gobeil, S., Montefiori, D.C., Korber, B., Saunders, K.O., Haynes, B.F., Henderson, R., Acharya, P.. DOI 10.1016/j.molcel.2024.06.028

SARS-CoV-2 Omicron XBB Lineage Spike Structures, Conformations, Antigenicity, and Receptor Recognition SSRN, 2024. Zhang, Q.E., Lindenberger, J., Parsons, R.J., Thakur, B., Parks, R., Park, C.S., Huang, X., Sammour, S., Janowska, K., Spence, T.N., Edwards, R.J., Martin, M., Williams, W.B., Gobeil, S., Montefiori, D.C., Korber, B., Saunders, K., Haynes, B.F., Henderson, R., Acharya, P.. DOI 10.2139/ssrn.4761075

Structural diversity of the SARS-CoV-2 Omicron spike bioRxiv, 2022. Gobeil, S.M.-C., Henderson, R., Stalls, V., Janowska, K., Huang, X., May, A., Speakman, M., Beaudoin, E., Manne, K., Li, D., Parks, R., Barr, M., Deyton, M., Martin, M., Mansouri, K., Edwards, R.J., Sempowski, G.D., Saunders, K.O., Wiehe, K., Williams, W., Korber, B., Haynes, B.F., Acharya, P.. DOI 10.1101/2022.01.25.477784

Structural diversity of the SARS-CoV-2 Omicron spike Molecular Cell, 2022. Gobeil, S.M.-C., Henderson, R., Stalls, V., Janowska, K., Huang, X., May, A., Speakman, M., Beaudoin, E., Manne, K., Li, D., Parks, R., Barr, M., Deyton, M., Martin, M., Mansouri, K., Edwards, R.J., Eaton, A., Montefiori, D.C., Sempowski, G.D., Saunders, K.O., Wiehe, K., Williams, W., Korber, B., Haynes, B.F., Acharya, P.. DOI 10.1016/j.molcel.2022.03.028

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike bioRxiv, 2022. Stalls, V., Lindenberger, J., Gobeil, S.M.-C., Henderson, R., Parks, R., Barr, M., Deyton, M., Martin, M., Janowska, K., Huang, X., May, A., Speakman, M., Beaudoin, E., Kraft, B., Lu, X., Edwards, R.J., Eaton, A., Montefiori, D.C., Williams, W., Saunders, K.O., Wiehe, K., Haynes, B.F., Acharya, P.. DOI 10.1101/2022.04.07.487528

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike Cell Reports, 2022. Stalls, V., Lindenberger, J., Gobeil, S.M.-C., Henderson, R., Parks, R., Barr, M., Deyton, M., Martin, M., Janowska, K., Huang, X., May, A., Speakman, M., Beaudoin, E., Kraft, B., Lu, X., Edwards, R.J., Eaton, A., Montefiori, D.C., Williams, W.B., Saunders, K.O., Wiehe, K., Haynes, B.F., Acharya, P.. DOI 10.1016/j.celrep.2022.111009

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice Science Translational Medicine, 2022. Martinez, D.R., Schäfer, A., Gobeil, S., Li, D., De la Cruz, G., Parks, R., Lu, X., Barr, M., Stalls, V., Janowska, K., Beaudoin, E., Manne, K., Mansouri, K., Edwards, R.J., Cronin, K., Yount, B., Anasti, K., Montgomery, S.A., Tang, J., Golding, H., Shen, S., Zhou, T., Kwong, P.D., Graham, B.S., Mascola, J.R., Montefiori, D.C., Alam, S.M., Sempowski, G.D., Khurana, S., Wiehe, K., Saunders, K.O., Acharya, P., Haynes, B.F., Baric, R.S.. DOI 10.1126/scitranslmed.abj7125

A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice 2021/04/28. David R. Martinez, Alexandra Schaefer, Sophie Gobeil, Dapeng Li, Gabriela De la Cruz, Robert Parks, Xiaozhi Lu, Maggie Barr, Kartik Manne, Katayoun Mansouri, Robert J. Edwards, Boyd Yount, Kara Anasti, Stephanie A. Montgomery, Shaunna Shen, Tongqing Zhou, Peter D. Kwong, Barney S. Graham, John R. Mascola, David. C. Montefiori, Munir Alam, Gregory D. Sempowski, Kevin Wiehe, Kevin O. Saunders, Priyamvada Acharya, Barton F. Haynes, Ralph S. Baric. DOI 10.1101/2021.04.27.441655

The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates bioRxiv, 2021. Li, D., Edwards, R.J., Manne, K., Martinez, D.R., Schäfer, A., Alam, S.M., Wiehe, K., Lu, X., Parks, R., Sutherland, L.L., Oguin, T.H., McDanal, C., Perez, L.G., Mansouri, K., Gobeil, S.M.C., Janowska, K., Stalls, V., Kopp, M., Cai, F., Lee, E., Foulger, A., Hernandez, G.E., Sanzone, A., Tilahun, K., Jiang, C., Tse, L.V., Bock, K.W., Minai, M., Nagata, B.M., Cronin, K., Gee-Lai, V., Deyton, M., Barr, M., Von Holle, T., Macintyre, A.N., Stover, E., Feldman, J., Hauser, B.M., Caradonna, T.M., Scobey, T.D., Moody, M.A., Cain, D.W., DeMarco, C.T., Denny, T.N., Woods, C.W., Petzold, E.W., Schmidt, A.G., Teng, I.-T., Zhou, T., Kwong, P.D., Mascola, J.R., Graham, B.S., Moore, I.N., Seder, R., Andersen, H., Lewis, M.G., Montefiori, D.C., Sempowski, G.D., Baric, R.S., Acharya, P., Haynes, B.F., Saunders, K.O.. DOI 10.1101/2020.12.31.424729

SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys bioRxiv, 2021. Saunders, K.O., Lee, E., Parks, R., Martinez, D.R., Li, D., Chen, H., Edwards, R.J., Gobeil, S., Barr, M., Mansouri, K., Alam, S.M., Sutherland, L.L., Cai, F., Sanzone, A.M., Berry, M., Manne, K., Kapingidza, A.B., Azoitei, M., Tse, L.V., Scobey, T.D., Spreng, R.L., Rountree, R.W., DeMarco, C.T., Denny, T.N., Woods, C.W., Petzold, E.W., Oguin, T.H., Sempowski, G.D., Gagne, M., Douek, D.C., Tomai, M.A., Fox, C.B., Seder, R., Wiehe, K., Weissman, D., Pardi, N., Acharya, P., Andersen, H., Lewis, M.G., Moore, I.N., Montefiori, D.C., Baric, R.S., Haynes, B.F.. DOI 10.1101/2021.02.17.431492

Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses Nature, 2021. Saunders, K.O., Lee, E., Parks, R., Martinez, D.R., Li, D., Chen, H., Edwards, R.J., Gobeil, S., Barr, M., Mansouri, K., Alam, S.M., Sutherland, L.L., Cai, F., Sanzone, A.M., Berry, M., Manne, K., Bock, K.W., Minai, M., Nagata, B.M., Kapingidza, A.B., Azoitei, M., Tse, L.V., Scobey, T.D., Spreng, R.L., Rountree, R.W., DeMarco, C.T., Denny, T.N., Woods, C.W., Petzold, E.W., Tang, J., Oguin, T.H., Sempowski, G.D., Gagne, M., Douek, D.C., Tomai, M.A., Fox, C.B., Seder, R., Wiehe, K., Weissman, D., Pardi, N., Golding, H., Khurana, S., Acharya, P., Andersen, H., Lewis, M.G., Moore, I.N., Montefiori, D.C., Baric, R.S., Haynes, B.F.. DOI 10.1038/s41586-021-03594-0

Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics to Design Selective and Nonimmunosuppressive FK506 Analogs mBio, 2021. Gobeil, S.M.-C., Bobay, B.G., Juvvadi, P.R., Christopher Cole, D., Heitman, J., Steinbach, W.J., Venters, R.A., Spicer, L.D.. DOI 10.1128/mBio.03000-21

In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies Cell, 2021. Li, D., Edwards, R.J., Manne, K., Martinez, D.R., Schäfer, A., Alam, S.M., Wiehe, K., Lu, X., Parks, R., Sutherland, L.L., Oguin, T.H., McDanal, C., Perez, L.G., Mansouri, K., Gobeil, S.M.C., Janowska, K., Stalls, V., Kopp, M., Cai, F., Lee, E., Foulger, A., Hernandez, G.E., Sanzone, A., Tilahun, K., Jiang, C., Tse, L.V., Bock, K.W., Minai, M., Nagata, B.M., Cronin, K., Gee-Lai, V., Deyton, M., Barr, M., Von Holle, T., Macintyre, A.N., Stover, E., Feldman, J., Hauser, B.M., Caradonna, T.M., Scobey, T.D., Rountree, W., Wang, Y., Moody, M.A., Cain, D.W., DeMarco, C.T., Denny, T.N., Woods, C.W., Petzold, E.W., Schmidt, A.G., Teng, I.-T., Zhou, T., Kwong, P.D., Mascola, J.R., Graham, B.S., Moore, I.N., Seder, R., Andersen, H., Lewis, M.G., Montefiori, D.C., Sempowski, G.D., Baric, R.S., Acharya, P., Haynes, B.F., Saunders, K.O.. DOI 10.1016/j.cell.2021.06.021

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies Cell, 2021. Williams, W.B., Meyerhoff, R.R., Edwards, R.J., Li, H., Manne, K., Nicely, N.I., Henderson, R., Zhou, Y., Janowska, K., Mansouri, K., Gobeil, S., Evangelous, T., Hora, B., Berry, M., Abuahmad, A.Y., Sprenz, J., Deyton, M., Stalls, V., Kopp, M., Hsu, A.L., Borgnia, M.J., Stewart-Jones, G.B.E., Lee, M.S., Bronkema, N., Moody, M.A., Wiehe, K., Bradley, T., Alam, S.M., Parks, R.J., Foulger, A., Oguin, T., Sempowski, G.D., Bonsignori, M., LaBranche, C.C., Montefiori, D.C., Seaman, M., Santra, S., Perfect, J., Francica, J.R., Lynn, G.M., Aussedat, B., Walkowicz, W.E., Laga, R., Kelsoe, G., Saunders, K.O., Fera, D., Kwong, P.D., Seder, R.A., Bartesaghi, A., Shaw, G.M., Acharya, P., Haynes, B.F.. DOI 10.1016/j.cell.2021.04.042

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity Science, 2021. Gobeil, S.M.-C., Janowska, K., McDowell, S., Mansouri, K., Parks, R., Stalls, V., Kopp, M.F., Manne, K., Li, D., Wiehe, K., Saunders, K.O., Edwards, R.J., Korber, B., Haynes, B.F., Henderson, R., Acharya, P.. DOI 10.1126/science.abi6226

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation and antigenicity bioRxiv, 2021. Gobeil, S.M.-C., Janowska, K., McDowell, S., Mansouri, K., Parks, R., Stalls, V., Kopp, M.F., Manne, K., Saunders, K., Edwards, R.J., Haynes, B.F., Henderson, R.C., Acharya, P.. DOI 10.1101/2021.03.11.435037

Development of sulfahydantoin derivatives as β-lactamase inhibitors Bioorganic and Medicinal Chemistry Letters, 2021. Paquet-Côté, P.-A., Alejaldre, L., Lapointe Verreault, C., Gobeil, S.M.C., Lamoureux, R., Bédard, L., Normandeau, C.-O., Lemay-St-Denis, C., Pelletier, J.N., Voyer, N.. DOI 10.1016/j.bmcl.2021.127781

D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization Cell Host and Microbe, 2021. Weissman, D., Alameh, M.-G., de Silva, T., Collini, P., Hornsby, H., Brown, R., LaBranche, C.C., Edwards, R.J., Sutherland, L., Santra, S., Mansouri, K., Gobeil, S., McDanal, C., Pardi, N., Hengartner, N., Lin, P.J.C., Tam, Y., Shaw, P.A., Lewis, M.G., Boesler, C., Şahin, U., Acharya, P., Haynes, B.F., Korber, B., Montefiori, D.C.. DOI 10.1016/j.chom.2020.11.012

D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction Cell Reports, 2021. Gobeil, S.M.-C., Janowska, K., McDowell, S., Mansouri, K., Parks, R., Manne, K., Stalls, V., Kopp, M.F., Henderson, R., Edwards, R.J., Haynes, B.F., Acharya, P.. DOI 10.1016/j.celrep.2020.108630

Cold sensitivity of the SARS-CoV-2 spike ectodomain Nature Structural and Molecular Biology, 2021. Edwards, R.J., Mansouri, K., Stalls, V., Manne, K., Watts, B., Parks, R., Janowska, K., Gobeil, S.M.C., Kopp, M., Li, D., Lu, X., Mu, Z., Deyton, M., Oguin, T.H., Sprenz, J., Williams, W., Saunders, K.O., Montefiori, D., Sempowski, G.D., Henderson, R., Munir Alam, S., Haynes, B.F., Acharya, P.. DOI 10.1038/s41594-020-00547-5

Cold sensitivity of the SARS-CoV-2 spike ectodomain [], 2020/07/13. DOI 10.1101/2020.07.12.199588

Leveraging fungal calcineurin-inhibitor structures, biophysics and dynamics to design selective and non-immunosuppressive FK506 analogs bioRxiv, 2020. Gobeil, S.M.-C., Bobay, B.G., Juvvadi, P.R., Cole, D.C., Heitman, J., Steinbach, W.J., Venters, R.A., Spicer, L.D.. DOI 10.1101/2020.04.14.039800

FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus Biochemical and Biophysical Research Communications, 2020. Juvvadi, P.R., Bobay, B.G., Gobeil, S.M.C., Cole, D.C., Venters, R.A., Heitman, J., Spicer, L.D., Steinbach, W.J.. DOI 10.1016/j.bbrc.2020.03.062

D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction bioRxiv, 2020. Gobeil, S.M.-C., Janowska, K., McDowell, S., Mansouri, K., Parks, R., Manne, K., Stalls, V., Kopp, M., Henderson, R., Edwards, R.J., Haynes, B.F., Acharya, P.. DOI 10.1101/2020.10.11.335299

D614G Spike mutation increases SARS CoV-2 susceptibility to neutralization medRxiv, 2020. Weissman, D., Alameh, M.-G., de Silva, T., Collini, P., Hornsby, H., Brown, R., LaBranche, C.C., Edwards, R.J., Sutherland, L., Santra, S., Mansouri, K., Gobeil, S., McDanal, C., Pardi, N., Hengartner, N., Lin, P.J.C., Tam, Y., Shaw, P.A., Lewis, M.G., Boesler, C., Şahin, U., Acharya, P., Haynes, B.F., Korber, B., Montefiori, D.C.. DOI 10.1101/2020.07.22.20159905

Controlling the SARS-CoV-2 spike glycoprotein conformation Nature Structural and Molecular Biology, 2020. Henderson, R., Edwards, R.J., Mansouri, K., Janowska, K., Stalls, V., Gobeil, S.M.C., Kopp, M., Li, D., Parks, R., Hsu, A.L., Borgnia, M.J., Haynes, B.F., Acharya, P.. DOI 10.1038/s41594-020-0479-4

Controlling the SARS-CoV-2 Spike Glycoprotein Conformation bioRxiv, 2020. Henderson, R., Edwards, R.J., Mansouri, K., Janowska, K., Stalls, V., Gobeil, S., Kopp, M., Hsu, A., Borgnia, M., Parks, R., Haynes, B.F., Acharya, P.. DOI 10.1101/2020.05.18.102087

The Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function Scientific Reports, 2019. Gobeil, S.M.C., Ebert, M.C.C.J.C., Park, J., Gagné, D., Doucet, N., Berghuis, A.M., Pleiss, J., Pelletier, J.N.. DOI 10.1038/s41598-019-42866-8

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents Nature Communications, 2019. Juvvadi, P.R., Fox, D., Bobay, B.G., Hoy, M.J., Gobeil, S.M.C., Venters, R.A., Chang, Z., Lin, J.J., Averette, A.F., Cole, D.C., Barrington, B.C., Wheaton, J.D., Ciofani, M., Trzoss, M., Li, X., Lee, S.C., Chen, Y.-L., Mutz, M., Spicer, L.D., Schumacher, M.A., Heitman, J., Steinbach, W.J.. DOI 10.1038/s41467-019-12199-1

¹⁵N, ¹³C and ¹H resonance assignments of FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus Biomolecular NMR Assignments, 2019. Gobeil, S.M.C., Bobay, B.G., Spicer, L.D., Venters, R.A.. DOI 10.1007/s12104-019-09878-x