Répertoire du corps professoral

Génération de produits sanguins in vitro grâce au développement d’un modèle de moelle osseuse humaine par génie tissulaire
Programme: Réseaux thématiques de recherche
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Santé
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2025 au 30 septembre 2026

Fonds de démarrage - Nouveau chercheur
Programme: Fonds de démarrage
Organisme(s) subventionnaire(s): CHU de Québec – Université Laval – CHUL
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 août 2025 au 31 mars 2027

Publications des 5 dernières années

A potent proresolving mediator 17R-resolvin D2 from human macrophages, monocytes, and saliva Science Advances, 2024/11/22. Mélissa Simard, Robert Nshimiyimana, Nan Chiang, Ana R. Rodriguez, Bernd W. Spur, Charles N. Serhan. DOI 10.1126/sciadv.adq4785

Biosynthesis of resolvin D1, resolvin D2, and RCTR1 from 7,8(S,S)-epoxytetraene in human neutrophils and macrophages Proceedings of the National Academy of Sciences, 2024/09/10. Robert Nshimiyimana, Mélissa Simard, Tarvi Teder, Ana R. Rodriguez, Bernd W. Spur, Jesper Z. Haeggström, Charles N. Serhan. DOI 10.1073/pnas.2405821121

Postmortem Fatty Acid Abnormalities in the Cerebellum of Patients with Essential Tremor The Cerebellum, 2024/08/31. Mélissa Simard, Koralie Mélançon, Line Berthiaume, Cyntia Tremblay, Laura Pshevorskiy, Pierre Julien, Ali H. Rajput, Alex Rajput, Frédéric Calon. DOI 10.1007/s12311-024-01736-4

The Impact of the CB2 Cannabinoid Receptor in Inflammatory Diseases: An Update Molecules, 2024/07/18. Volatiana Rakotoarivelo, Thomas Z. Mayer, Mélissa Simard, Nicolas Flamand, Vincenzo Di Marzo. DOI 10.3390/molecules29143381

Pharmacological evidence that the inhibitory effects of prostaglandin E2 are mediated by the EP2 and EP4 receptors in human neutrophils Journal of Leukocyte Biology, 2024/05/29. Jean-Philippe C Lavoie, Mélissa Simard, Hilal Kalkan, Volatiana Rakotoarivelo, Sandrine Huot, Vincenzo Di Marzo, Andréanne Côté, Marc Pouliot, Nicolas Flamand. DOI 10.1093/jleuko/qiae029

N-eicosapentaenoyl-ethanolamine decreases the proliferation of psoriatic keratinocytes in a reconstructed psoriatic skin model Scientific Reports, 2023/07/26. Mélissa Simard, Andréa Tremblay, Sophie Morin, Geneviève Rioux, Nicolas Flamand, Roxane Pouliot. DOI 10.1038/s41598-023-39185-4

Stereochemistry and functions of the new cysteinyl‐resolvin, 4S,5R‐RCTR1, in efferocytosis and erythrophagocytosis of human senescent erythrocytes American Journal of Hematology, 2023/07. Robert Nshimiyimana, Stephania Libreros, Mélissa Simard, Nan Chiang, Ana R. Rodriguez, Bernd W. Spur, Jesper Z. Haeggström, Charles N. Serhan. DOI 10.1002/ajh.26932

Biosynthesis and metabolism of endocannabinoids and their congeners from the monoacylglycerol and N-acyl-ethanolamine families Biochemical Pharmacology, 2022/11. Mélissa Simard, Anne-Sophie Archambault, Jean-Philippe C. Lavoie, Élizabeth Dumais, Vincenzo Di Marzo, Nicolas Flamand. DOI 10.1016/j.bcp.2022.115261

Current knowledge of the implication of lipid mediators in psoriasis Frontiers in Immunology, 2022/08/26. Mélissa Simard, Sophie Morin, Zainab Ridha, Roxane Pouliot. DOI 10.3389/fimmu.2022.961107

Remodeling of the Dermal Extracellular Matrix in a Tissue-Engineered Psoriatic Skin Model by n-3 Polyunsaturated Fatty Acids Biomedicines, 2022/05. Mélissa Simard, Alexe Grenier, Geneviève Rioux, Andréa Tremblay, Isalie Blais, Nicolas Flamand, Roxane Pouliot. DOI 10.3390/biomedicines10051078

Alpha-Linolenic Acid Modulates T Cell Incorporation in a 3D Tissue-Engineered Psoriatic Skin Model Cells, 2022/04/30. Sophie Morin, Mélissa Simard, Geneviève Rioux, Pierre Julien, Roxane Pouliot. DOI 10.3390/cells11091513

α-Linolenic acid and linoleic acid modulate the lipidome and the skin barrier of a tissue-engineered skin model Acta Biomaterialia, 2022/03. Mélissa Simard, Andréa Tremblay, Sophie Morin, Cyril Martin, Pierre Julien, Julie Fradette, Nicolas Flamand, Roxane Pouliot. DOI 10.1016/j.actbio.2021.11.021

Expression and Functions of the CB2 Receptor in Human Leukocytes Frontiers in Pharmacology, 2022/02/22. Mélissa Simard, Volatiana Rakotoarivelo, Vincenzo Di Marzo, Nicolas Flamand. DOI 10.3389/fphar.2022.826400

Docosahexaenoic Acid Modulates Paracellular Absorption of Testosterone and Claudin-1 Expression in a Tissue-Engineered Skin Model International Journal of Molecular Sciences, 2021/12. Andréa Tremblay, Mélissa Simard, Sophie Morin, Roxane Pouliot. DOI 10.3390/ijms222313091

Development of a 3D psoriatic skin model optimized for infiltration of IL-17A producing T cells: Focus on the crosstalk between T cells and psoriatic keratinocytes Acta Biomaterialia, 2021/12. Geneviève Rioux, Mélissa Simard, Sophie Morin, Isabelle Lorthois, Sylvain L. Guérin, Roxane Pouliot. DOI 10.1016/j.actbio.2021.09.018

Biological action of docosahexaenoic acid in a 3D tissue-engineered psoriatic skin model: Focus on the PPAR signaling pathway Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2021/12. Sophie Morin, Mélissa Simard, Nicolas Flamand, Roxane Pouliot. DOI 10.1016/j.bbalip.2021.159032

Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils Cells, 2021/09/05. Anne-Sophie Archambault, Francesco Tinto, Élizabeth Dumais, Volatiana Rakotoarivelo, Magdalena Kostrzewa, Pier-Luc Plante, Cyril Martin, Mélissa Simard, Cristoforo Silvestri, Roxane Pouliot, Michel Laviolette, Louis-Philippe Boulet, Rosa Maria Vitale, Alessia Ligresti, Vincenzo Di Marzo, Nicolas Flamand. DOI 10.3390/cells10092322

Synthesis and molecular targets of N-13-hydroxy-octadienoyl-ethanolamine, a novel endogenous bioactive 15-lipoxygenase-derived metabolite of N-linoleoyl-ethanolamine found in the skin and saliva Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2021/08. DOI 10.1016/j.bbalip.2021.158954

Investigation of Omega-3 Polyunsaturated Fatty Acid Biological Activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells Journal of Investigative Dermatology, 2021/04. DOI 10.1016/j.jid.2021.02.755

Transcriptome Profiling Analyses in Psoriasis: A Dynamic Contribution of Keratinocytes to the Pathogenesis Genes, 2020/09/30. DOI 10.3390/genes11101155

A Tissue-Engineered Human Psoriatic Skin Model to Investigate the Implication of cAMP in Psoriasis: Differential Impacts of Cholera Toxin and Isoproterenol on cAMP Levels of the Epidermis International Journal of Molecular Sciences, 2020/07/23. DOI 10.3390/ijms21155215