Répertoire du corps professoral
Marie-Annick Clavel
Professeure titulaire
Marie-Annick.Clavel@criucpq.ulaval.ca
Pavillon Ferdinand-Vandry
1050, avenue de la Médecine
Local 4211
Imaging Substudy of the BEST Trial: Balloon-Expandable versus Self-expanding Transcatheter Heart Valve for Treatment of Symptomatic Native Aortic Valve Stenosis
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2022
au 30 septembre 2027
Blocking the Effects of Serotonin to Prevent Ischemic Mitral Regurgitation: a Randomized Trial
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2022
au 31 mars 2027
Impact of an Angiotensin Receptor Blocker in Aortic Stenosis - a Randomized Controlled Trial
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2021
au 31 mars 2026
Canada Research Chair in Women Valvular Heart Health
Programme: Chaires de recherche du Canada - Fonctionnement
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2020
au 30 juin 2025
Financements des 2 dernières années
Les différences sexuelles en culture de cellules intersitielles de valve aortique
Programme: Fonds des leaders John-R.-Evans (FLJR)
Organisme(s) subventionnaire(s): Fondation IUCPQ, Ministère de la Santé et des Services sociaux, Fondation Canadienne pour l'innovation (La)
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juin 2023
au 31 mai 2024
Économie salariale générée par mandat CPAUL utilisée en fonds de recherche
Organisme(s) subventionnaire(s): Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 septembre 2022
au 31 août 2024
Un nano-vaccin contre les maladies cardiovasculaires
Programme: Audace
Organisme(s) subventionnaire(s): Fonds de recherche du Québec - Société et culture
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2020
au 31 mars 2024
Elucidating the role of lipoprotein(a) in calcific aortic valve stenosis using novel proteomic and imaging approaches
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2019
au 30 septembre 2023
Sex-dependent differences in pathophysiological mechanisms, presentation, outcome, and treatment of aortic valve stenosis
Programme: Bourse de nouveau chercheur
Organisme(s) subventionnaire(s): Fondation des maladies du coeur et de l'AVC du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 juillet 2019
au 30 juin 2023
Stage d'été « Carrière été »
Programme: Emplois d'été Canada
Organisme(s) subventionnaire(s): Emploi et Développement Social Canada (EDSC)
Type de financement: Subvention
Établissement tête: Université Laval
Du 15 mai 2017
au 25 août 2023
Encadrements terminés dans les 5 dernières années
Publications des 5 dernières années
Von Willebrand Factor Activity Association With Outcomes After Transcatheter Edge-to-Edge Mitral Valve Repair JACC: Advances, 2024/10. Sandra Hadjadj, Philippe Pibarot, Caroline Gravel, Marie-Annick Clavel, Ons Marsit, Dounia Rouabhia, Benoît M. Labbé, Kim O’Connor, Mathieu Bernier, Erwan Salaun, Julio Farjat-Pasos, Jorge Nuche Berenguer, Josep Rodés-Cabau, Jean-Michel Paradis, Jonathan Beaudoin. DOI 10.1016/j.jacadv.2024.101242
Sex-Specific Functional Status Decline and Outcomes in Mild-to-Moderate Aortic Stenosis JACC: Advances, 2024/10. Lionel Tastet, Mylène Shen, Romain Capoulade, Marie Arsenault, Élisabeth Bédard, Kathia Abdoun, Marie-Ange Fleury, Nancy Côté, Philippe Pibarot, Marie-Annick Clavel. DOI 10.1016/j.jacadv.2024.101267
Prognostic value of aortic valve calcification in non-severe aortic stenosis with preserved ejection fraction European Heart Journal - Cardiovascular Imaging, 2024/09/30. Zi Ye, Christopher G Scott, Rohan A Gajjar, Thomas Foley, Marie-Annick Clavel, Vuyisile T Nkomo, S Allen Luis, William R Miranda, Ratnasari Padang, Sorin V Pislaru, Maurice Enriquez-Sarano, Hector I Michelena. DOI 10.1093/ehjci/jeae145
Molecular Features of Calcific Aortic Stenosis in Female and Male Patients CJC Open, 2024/09. Emma Le Nezet, Chloé Marqueze-Pouey, Isabelle Guisle, Marie-Annick Clavel. DOI 10.1016/j.cjco.2024.06.002
Early Aortic Valve Replacement in Moderate Aortic Stenosis JACC: Advances, 2024/09. Omar M. Abdelfattah, Xander Jacquemyn, Samir R. Kapadia, Nicolas M. Van Mieghem, Marie-Annick Clavel, Philippe Généreux, Martin Leon, Philippe Pibarot. DOI 10.1016/j.jacadv.2024.101190
Diffuse Interstitial Fibrosis of the Myocardium Predicts Outcome in Moderate and Asymptomatic Severe Aortic Stenosis JACC: Cardiovascular Imaging, 2024/09. Hyun-Jung Lee, Anvesha Singh, Jaehyun Lim, Neil Craig, Rong Bing, Lionel Tastet, Jun-Bean Park, Hyung-Kwan Kim, Yong-Jin Kim, Marie-Annick Clavel, Bernhard L. Gerber, Gerry P. McCann, Marc R. Dweck, Phillipe Pibarot, Seung-Pyo Lee. DOI 10.1016/j.jcmg.2024.08.003
Left and right ventricular longitudinal systolic function following aortic valve replacement in the PARTNER 2 trial and registry European Heart Journal - Cardiovascular Imaging, 2024/08/26. Iria Silva, Julien Ternacle, Rebecca T Hahn, Mohamed Salah-Annabi, Abdellaziz Dahou, Laura Krapf, Erwan Salaun, Ezequiel Guzzetti, Ke Xu, Marie-Annick Clavel, Mathieu Bernier, Jonathan Beaudoin, Paul C Cremer, Wael Jaber, Leonardo Rodriguez, Federico M Asch, Neil J Weismann, Jeroen Bax, Nina Ajmone, Maria C Alu, Faouzi Kallel, Michael J Mack, John G Webb, Samir Kapadia, Raj Makkar, Susheel Kodali, Howard C Herrmann, Vinod Thourani, Martin B Leon, Philippe Pibarot. DOI 10.1093/ehjci/jeae114
Adjudication of Low-Flow, Low-Gradient Aortic Stenosis Severity JACC: Cardiovascular Imaging, 2024/08. Marie-Annick Clavel, Philippe Pibarot. DOI 10.1016/j.jcmg.2024.04.018
Sex Differences in Aortic Stenosis: From the Pathophysiology to the Intervention, Current Challenges, and Future Perspectives Journal of Clinical Medicine, 2024/07/19. Paolo Springhetti, Kathia Abdoun, Marie-Annick Clavel. DOI 10.3390/jcm13144237
Cardiac Damage Staging Predicts Outcomes in Aortic Valve Stenosis After Aortic Valve Replacement JACC: Advances, 2024/05. Omar M. Abdelfattah, Xander Jacquemyn, Michel Pompeu Sá, Hani Jneid, Ibrahim Sultan, David J. Cohen, Linda D. Gillam, Lucy Aron, Marie-Annick Clavel, Philippe Pibarot, Jeroen J. Bax, Samir R. Kapadia, Martin Leon, Philippe Généreux. DOI 10.1016/j.jacadv.2024.100959
Computed tomography calcium scoring in aortic stenosis: bicuspid versus tricuspid morphology Heart, 2024/04. Zi Ye, Marie-Annick Clavel, Thomas A Foley, Philippe Pibarot, Maurice Enriquez-Sarano, Hector I Michelena. DOI 10.1136/heartjnl-2023-323281
Impact of Prosthesis-Patient Mismatch After Surgical Aortic Valve Replacement: Systematic Review and Meta-Analysis of Reconstructed Time-to-Event Data of 122 989 Patients With 592 952 Patient-Years. Journal of the American Heart Association, 2024/03/27. Michel Pompeu Sá, Xander Jacquemyn, Jef Van den Eynde, Danny Chu, Derek Serna-Gallegos, Tjark Ebels, Marie-Annick Clavel, DVM, PhD, FACC, FAHA, FCCS, Philippe Pibarot, Ibrahim Sultan. DOI 10.1161/jaha.123.033176
Angiotensin II receptor blockers are associated with reduced valvular fibrosis in females with aortic stenosis. The Canadian journal of cardiology, 2024/03/20. Carter-Storch R, Le Nezet E, Ali M, Powers A, Haujir A, Demers K, Couture C, Dumont É, Trahan S, Pagé S, Dagenais F, Pibarot P, Dahl JS, Clavel MA. DOI 10.1016/j.cjca.2024.03.009
Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation. Nature communications, 2024/03/18. Sébastien Thériault, Zhonglin LI, Erik Abner, Jian'an Luan, Hasanga Dilshan Manikpurage, Ursula Houessou, Zamani P, BRIEND mewen, Estonian Biobank Research Team, Dominique K. Boudreau, Nathalie Gaudreault, Frenette L, Argaud D, Dahmene M, Dagenais F, Marie-Annick Clavel, DVM, PhD, FACC, FAHA, FCCS, Pibarot P, Benoit Arsenault, Boekholdt SM, Nicholas Wareham, Esko T, Patrick Mathieu, Yohan Bossé. DOI 10.1038/s41467-024-46639-4
Prevalence and Outcomes of Patients With Discordant High-Gradient Aortic Stenosis. Journal of the American College of Cardiology, 2024/03/01. Unger P, Powers A, Le Nezet E, Lacasse-Rioux E, Xavier Galloo, Clavel MA. DOI 10.1016/j.jacc.2024.01.025
The Canadian Women's Heart Health Alliance ATLAS on the Epidemiology, Diagnosis, and Management of Cardiovascular Disease in Women - Chapter 9: Summary of Current Status, Challenges, Opportunities, and Recommendations. CJC open, 2023/12/07. Mulvagh SL, Colella TJF, Gulati M, Crosier R, Allana S, Randhawa VK, Bruneau J, Pacheco C, Jaffer S, Cotie L, Mensour E, Clavel MA, Hill B, Kirkham AA, Foulds H, Liblik K, Van Damme A, Grace SL, Bouchard K, Tulloch H, Robert H, Pike A, Benham JL, Tegg N, Parast N, Adreak N, Boivin-Proulx LA, Parry M, Gomes Z, Sarfi H, Iwegim C, Van Spall HGC, Nerenberg KA, Wright SP, Limbachia JA, Mullen KA, Norris CM. DOI 10.1016/j.cjco.2023.12.001
Impact of mandatory preoperative dental screening on post-procedural risk of infective endocarditis in patients undergoing transcatheter aortic valve implantation: a nationwide retrospective observational study. The Lancet regional health. Europe, 2023/11/22. Krasniqi L, Schødt Riber LP, Nissen H, Terkelsen CJ, Andersen NH, Freeman P, Povlsen JA, Gerke O, Clavel MA, Jordi Dahl. DOI 10.1016/j.lanepe.2023.100789
The Canadian Women's Heart Health Alliance ATLAS on the Epidemiology, Diagnosis, and Management of Cardiovascular Disease in Women - Chapter 8: Knowledge Gaps and Status of Existing Research Programs in Canada. CJC open, 2023/11/17. Clavel MA, Van Spall HGC, Mantella LE, Foulds H, Randhawa V, Parry M, Liblik K, Kirkham AA, Cotie L, Jaffer S, Bruneau J, Colella TJF, Ahmed S, Dhukai A, Gomes Z, Adreak N, Keeping-Burke L, Limbachia J, Liu S, Jacques KE, Mullen KA, Mulvagh SL, Norris CM. DOI 10.1016/j.cjco.2023.11.013
Midterm Survival of Low‐Risk Patients Treated With Transcatheter Versus Surgical Aortic Valve Replacement: Meta‐Analysis of Reconstructed Time‐to‐Event Data Journal of the American Heart Association, 2023/11/07. Michel Pompeu Sá, Xander Jacquemyn, Jef Van den Eynde, Derek Serna‐Gallegos, Danny Chu, Marie‐Annick Clavel, Philippe Pibarot, Ibrahim Sultan. DOI 10.1161/JAHA.123.030012
Unique Aspects of Women's Valvular Heart Diseases: Impact for Diagnosis and Treatment. CJC open, 2023/11/04. Powers A, Lavoie N, Le Nezet E, Clavel MA. DOI 10.1016/j.cjco.2023.10.017
Reply JACC: Cardiovascular Imaging, 2023/09. Michel Pompeu Sá, Xander Jacquemyn, Jef Van den Eynde, Phillipe Pibarot, Marie-Annick Clavel, DVM, PhD, FACC, FAHA, FCCS. DOI 10.1016/j.jcmg.2023.06.015
Calcium Scoring to Classify Aortic Valve Stenosis Severity: What Is the Current Data? Current Cardiology Reports, 2023/09. Andréanne Powers, Marie-Annick Clavel. DOI 10.1007/s11886-023-01929-z
Performance of Computed Tomographic Angiography–Based Aortic Valve Area for Assessment of Aortic Stenosis Journal of the American Heart Association, 2023/08/15. Jerry Ash, Gurmandeep S. Sandhu, Jose Arriola‐Montenegro, Dzhalal Agakishiev, Marie‐Annick Clavel, Philippe Pibarot, Sue Duval, Prabhjot S. Nijjar. DOI 10.1161/JAHA.123.029973
Mid-term clinical and echocardiographic results of the INSPIRIS RESILIA aortic valve: a retrospective comparison to the Magna Ease Interdisciplinary CardioVascular and Thoracic Surgery, 2023/07/19. Jérémy Bernard, Gabriel Georges, Sébastien Hecht, Philippe Pibarot, Marie-Annick Clavel, Shervin Babaki, Dimitri Kalavrouziotis, Siamak Mohammadi. DOI 10.1093/icvts/ivad117
Association Between Remnant Cholesterol and Progression of Bioprosthetic Valve Degeneration 2023/07/05. Marie-Annick Clavel, Patrick Mathieu, Philippe Pibarot. DOI 10.1093/ehjci/jead159
Prognostic utility of N-terminal pro B-type natriuretic peptide ratio in mixed aortic valve disease Open Heart, 2023/07. Jérémy Bernard, Guillaume Jean, David Bienjonetti-Boudreau, Frédéric Jacques, Lionel Tastet, Erwan Salaun, Marie-Annick Clavel. DOI 10.1136/openhrt-2023-002361
Aortic Valvular Stenosis and Heart Failure : Advances in Diagnostic, Management, and Intervention Heart Fail Clin, 2023/07.
MULTI-MODALITY IMAGING IN AORTIC STENOSIS: AN EACVI CLINICAL CONSENSUS DOCUMENT 2023/06/30. Marc R Dweck, gilbert habib, Marie-Annick Clavel, patrizio lancellotti, Erwan Donal. DOI 10.1093/ehjci/jead153
Effect of race on pressure recovery adjustment for prevention of aortic stenosis grading discordance Heart, 2023/05/05. , Mylène Shen, Ezequiel Guzzetti, Lionel Tastet, Krithika Loganath, Simona Botezatu, Seung-Ah Lee, Sahmin Lee, Dae-Hee Kim, Jong-Min Song, Duk-Hyun Kang, marc dweck, Philippe Pibarot, Marie-Annick Clavel, DVM, PhD, FACC, FAHA, FCCS, Jae-Kwan Song. DOI 10.1136/heartjnl-2023-322586
Transcatheter Aortic Valve Replacement in Patients With Reduced Ejection Fraction and Nonsevere Aortic Stenosis Circulation: Cardiovascular Interventions, 2023/05. Sebastian Ludwig, Niklas Schofer, Mohamed Abdel-Wahab, Marina Urena, Guillaume Jean, Matthias Renker, Christian W. Hamm, Holger Thiele, Bernard Iung, Joris Ooms, Maya Wiessman, Mogensen, NSB, Benjamin Longère, Nils Perrin, Walid Ben Ali, Augustin Coisne, Jordi S. Dahl, Nicolas Van Mieghem, Ran Kornowski, Won-Keun Kim, Marie-Annick Clavel, DVM, PhD, FACC, FAHA, FCCS. DOI 10.1161/circinterventions.122.012768
Catheter-Induced Postextrasystolic Potentiation in the Assessment of Severity of Low-Gradient Aortic Valve Stenosis Circulation: Cardiovascular Interventions, 2023/05. Payam Dehghani, Jyotpal Singh, Zachary Singer, Jeffrey Booker, Andrea J. Lavoie, Rodney H. Zimmermann, Jay S. Shavadia, John G. Webb, Marie-Annick Clavel, Philippe Pibarot. DOI 10.1161/CIRCINTERVENTIONS.123.012892
Dobutamine Stress Echocardiography in Low-Gradient Aortic Stenosis 2023/03/01. Nils Sofus Borg Mogensen, Mulham Ali, Rasmus Carter-Storch, Mohamed-Salah Annabi, Jasmine Grenier-Delaney, Jacob Eifer Møller, Kristian Altern Øvrehus, Patricia A Pellikka, Philippe Pibarot, Marie-Annick Clavel, Jordi Sanchez Dahl. DOI 10.1101/2023.02.27.23286540
Coaptation Length as Predictor of Recurrent Mitral Regurgitation After Surgical Repair for Degenerative Mitral Valve Disease: Meta-Analysis of Reconstructed Time-to-Event Data. Structural heart : the journal of the Heart Team, 2023/01/19. Sá MP, Jacquemyn X, Van den Eynde J, Erten O, Caldonazo T, Doenst T, Marin-Cuartas M, Borger MA, Clavel MA, Pibarot P, Rodriguez R, Ramlawi B, Goldman S. DOI 10.1016/j.shj.2022.100152
Hemodynamic changes during aortic valve surgery among patients with aortic stenosis. Scandinavian cardiovascular journal : SCJ, 2022/12/01. DOI 10.1080/14017431.2022.2099008
Impact of Paravalvular Leak on Outcomes After Transcatheter Aortic Valve Implantation: Meta-Analysis of Kaplan-Meier-derived Individual Patient Data. Structural heart : the journal of the Heart Team, 2022/11/14. Sá MP, Jacquemyn X, Van den Eynde J, Tasoudis P, Erten O, Sicouri S, Macedo FY, Pasala T, Kaple R, Weymann A, Ruhparwar A, Clavel MA, Pibarot P, Ramlawi B. DOI 10.1016/j.shj.2022.100118
Percutaneous Transcatheter Edge-to-Edge Mitral Valve Repair With MitraClip System in the Era of G4. Structural heart : the journal of the Heart Team, 2022/11/12. Silva I, Turgeon PY, Paradis JM, Beaudoin J, O'Connor K, Ternacle J, Alperi A, Panagides V, Mesnier J, Gravel C, Clavel MA, Dagenais F, Dumont E, Mohammadi S, Pibarot P, Bernier M, Rodés-Cabau J, Salaun E. DOI 10.1016/j.shj.2022.100114
Hemodynamic and Clinical Outcomes in Redo-Surgical Aortic Valve Replacement vs. Transcatheter Valve-in-Valve Structural Heart, 2022/11. Sébastien Hecht, Anne-Sophie Zenses, Jérémy Bernard, Lionel Tastet, Nancy Côté, Leonardo Guimaraes, Jean-Michel Paradis, Jonathan Beaudoin, Kim O’Connor, Mathieu Bernier, Eric Dumont, Dimitri Kalavrouziotis, Robert Delarochellière, Siamak Mohammadi, Marie-Annick Clavel, DVM, PhD, FACC, FAHA, FCCS, Josep Rodés-Cabau, erwan salaun, Philippe Pibarot. DOI 10.1016/j.shj.2022.100106
Underestimation of Aortic Stenosis Severity by Doppler Mean Gradient During Atrial Fibrillation: Insights from Aortic Valve Weight. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2022/10/10. Marie-Annick Clavel, DVM, PhD, FACC, FAHA, FCCS, Alkurashi AK, Thaden JJ, Naser JA, El-Am E, Pislaru SV, Greason KL, Negrotto SM, Clavel MA, Pellikka PA, Maleszewski JJ, Nkomo VT. DOI 10.1016/j.echo.2022.10.007
Late Outcomes of Permanent Pacemaker Implantation After TAVR: Meta-analysis of Reconstructed Time-to-Event Data Journal of the Society for Cardiovascular Angiography & Interventions, 2022/09. Michel Pompeu Sá, Xander Jacquemyn, Tian Sun, Jef Van den Eynde, Panagiotis Tasoudis, Ozgun Erten, Serge Sicouri, Gianluca Torregrossa, Marie-Annick Clavel, Philippe Pibarot, Basel Ramlawi. DOI 10.1016/j.jscai.2022.100434
Impact of Right Ventricle-Pulmonary Artery Coupling on Clinical Outcomes in the PARTNER 3 Trial. JACC. Cardiovascular interventions, 2022/09/01. Marie-Annick Clavel, DVM, PhD, FACC, FAHA, FCCS, Cahill TJ, Pibarot P, Yu X, Babaliaros V, Blanke P, Clavel MA, Pamela Douglas, Khalique OK, Leipsic J, Makkar R, Alu MC, Kodali S, Mack MJ, Leon MB, Hahn RT. DOI 10.1016/j.jcin.2022.07.005
Live longer and better without aortic valve stenosis. The Lancet. Healthy longevity, 2022/08/18. Marie-Annick Clavel, DVM, PhD, FACC, FAHA, FCCS, Pibarot P, Clavel MA. DOI 10.1016/s2666-7568(22)00188-x
Impact of sex and sex hormones on pathophysiology and progression of aortic stenosis in a murine model. Physiological reports, 2022/08/01. Marie-Annick Clavel, DVM, PhD, FACC, FAHA, FCCS. DOI 10.14814/phy2.15433
Effects of Cyproheptadine on Mitral Valve Remodeling and Regurgitation After Myocardial Infarction. Journal of the American College of Cardiology, 2022/08/01. Marie-Annick Clavel, DVM, PhD, FACC, FAHA, FCCS. DOI 10.1016/j.jacc.2022.05.025
Association Between Early Left Ventricular Ejection Fraction Improvement After Transcatheter Aortic Valve Replacement and 5-Year Clinical Outcomes. JAMA cardiology, 2022/07/27. Marie-Annick Clavel, DVM, PhD, FACC, FAHA, FCCS. DOI 10.1001/jamacardio.2022.2222
Significance of Left Ventricular Ejection Time in Primary Mitral Regurgitation. The American journal of cardiology, 2022/06/28. DOI 10.1016/j.amjcard.2022.05.019
Case Report: Posterior Thoracic Window in the Presence of Pleural Effusion in Critical Care Medicine: One More Chance to Image the Aortic Valve. Frontiers in cardiovascular medicine, 2022/06/23. DOI 10.3389/fcvm.2022.907168
Long-Term Outcomes of Ross Procedure versus Mechanical Aortic Valve Replacement: Meta-Analysis of Reconstructed Time-To-Event Data. Trends in cardiovascular medicine, 2022/06/22. DOI 10.1016/j.tcm.2022.06.005
Temporal trends of aortic stenosis and comorbid chronic kidney disease in the province of Quebec, Canada. Open heart, 2022/06/01. DOI 10.1136/openhrt-2021-001923
Progression of aortic stenosis after an acute myocardial infarction. Open heart, 2022/06/01. DOI 10.1136/openhrt-2022-002046
Comprehensive myocardial characterization using cardiac magnetic resonance associates with outcomes in low gradient severe aortic stenosis. European heart journal. Cardiovascular Imaging, 2022/05/25. DOI 10.1093/ehjci/jeac089
Computed Tomography Aortic Valve Calcium Scoring in Patients With Bicuspid Aortic Valve Stenosis. Structural heart : the journal of the Heart Team, 2022/04/26. Shen M, Oh JK, Guzzetti E, Singh GK, Pawade T, Tastet L, Clavel MA, Delgado V, Bax JJ, Dweck MR, Abbas AE, Mando R, Falconi ML, Perez de Arenaza D, Poh KK, Kong W, Tay E, Pressman G, Brito D, Song JK, Pibarot P. DOI 10.1016/j.shj.2022.100027
The Canadian Women's Heart Health Alliance Atlas on the Epidemiology, Diagnosis, and Management of Cardiovascular Disease in Women - Chapter 6: Sex- and Gender-Specific Diagnosis and Treatment. CJC open, 2022/04/19. DOI 10.1016/j.cjco.2022.04.002
Sex Differences in the Progression of Aortic Valve Calcification and Clinical Outcomes: The PROGRESSA Study. JACC. Cardiovascular imaging, 2022/04/13. DOI 10.1016/j.jcmg.2022.02.015
Evolution of the burden of aortic stenosis by sex in the province of Quebec between 2006 and 2018. Heart (British Cardiac Society), 2022/03/21. DOI 10.1136/heartjnl-2021-319848
Cardiac Damage Staging Classification in Asymptomatic Moderate or Severe Primary Mitral Regurgitation. Structural heart : the journal of the Heart Team, 2022/03/12. Bernard J, Altes A, Dupuis M, Toubal O, Mahjoub H, Tastet L, Côté N, Clavel MA, Dumortier H, Tartar J, O'Connor K, Bernier M, Beaudoin J, Maréchaux S, Pibarot P. DOI 10.1016/j.shj.2022.100004
Patient Care Journey for Patients with Heart Valve Disease. The Canadian journal of cardiology, 2022/03/02. DOI 10.1016/j.cjca.2022.02.025
Incremental Prognostic Value of Semiautomated Left Ventricular Strain to BNP in Asymptomatic Aortic Stenosis. JACC. Cardiovascular imaging, 2022/02/16. DOI 10.1016/j.jcmg.2021.11.021
Stress exercise haemodynamic performance and opening reserve of a stented bovine pericardial aortic valve bioprosthesis. Journal of cardiac surgery, 2022/01/12. DOI 10.1111/jocs.16220
Accuracy of stroke volume measurement with phase-contrast cardiovascular magnetic resonance in patients with aortic stenosis Journal of Cardiovascular Magnetic Resonance, 2021/12. DOI 10.1186/s12968-021-00814-4
Clinical Value of Stress Transaortic Flow Rate During Dobutamine Echocardiography in Reduced Left Ventricular Ejection Fraction, Low-Gradient Aortic Stenosis: A Multicenter Study Circulation: Cardiovascular Imaging, 2021/11/08. DOI 10.1161/circimaging.121.012809
Bioprosthetic Mitral Valve Thrombosis: A Multifaceted and Challenging Clinical and Imaging Spectrum. JACC. Cardiovascular imaging, 2021/11/06. DOI 10.1016/j.jcmg.2021.08.023
Echocardiographic Variables Associated with Transvalvular Gradient after a Transcatheter Edge-to-Edge Mitral Valve Repair. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2021/10/12. DOI 10.1016/j.echo.2021.09.015
Multiparametric Approach for the Assessment of Mechanical Prosthetic Tricuspid Leaflet Function. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2021/09/08. DOI 10.1016/j.echo.2021.09.001
Reply: Calcium Score to Specify Assessment of Low-Flow Aortic Stenosis Severity. Journal of the American College of Cardiology, 2021/09/01. DOI 10.1016/j.jacc.2021.07.011
Markers of Myocardial Damage Predict Mortality in Patients With Aortic Stenosis. Journal of the American College of Cardiology, 2021/08/01. DOI 10.1016/j.jacc.2021.05.047
Sex-Specific Associations of Genetically-Predicted Circulating Lipoprotein(a) and Hepatic LPA Gene Expression Levels with Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses. Circulation. Genomic and precision medicine, 2021/07/19. DOI 10.1161/circgen.120.003271
Prosthesis-Patient Mismatch After Aortic Valve Replacement in the PARTNER 2 Trial and Registry. JACC. Cardiovascular interventions, 2021/07/01. DOI 10.1016/j.jcin.2021.03.069
Validation of aortic valve calcium quantification thresholds measured by computed tomography in Asian patients with calcific aortic stenosis European Heart Journal - Cardiovascular Imaging, 2021/06/25. DOI 10.1093/ehjci/jeab116
Moderate Aortic Stenosis in Patients With Heart Failure and Reduced Ejection Fraction Journal of the American College of Cardiology, 2021/06. DOI 10.1016/j.jacc.2021.04.014
Left ventricular asymmetric remodeling and subclinical left ventricular dysfunction in patients with calcific aortic valve stenosis – Results from a subanalysis of the PROGRESSA study International Journal of Cardiology, 2021/06. DOI 10.1016/j.ijcard.2021.03.017
Early benefits of bariatric surgery on subclinical cardiac function: Contribution of visceral fat mobilization Metabolism, 2021/06. DOI 10.1016/j.metabol.2021.154773
Doppler Velocity Index Outcomes Following Surgical or Transcatheter Aortic Valve Replacement in the PARTNER Trials JACC: Cardiovascular Interventions, 2021/06. DOI 10.1016/j.jcin.2021.04.007
Impact of sex on the management and outcome of aortic stenosis patients European Heart Journal, 2021/05/23. DOI 10.1093/eurheartj/ehab242
Reply JACC: Cardiovascular Interventions, 2021/05. DOI 10.1016/j.jcin.2021.03.029
Low-Flow Aortic Stenosis JACC: Cardiovascular Imaging, 2021/05. DOI 10.1016/j.jcmg.2021.01.026
A Machine-Learning Framework to Identify Distinct Phenotypes of Aortic Stenosis Severity JACC: Cardiovascular Imaging, 2021/05. DOI 10.1016/j.jcmg.2021.03.020
Flexibility of microstructural adaptations in airway smooth muscle Journal of Applied Physiology, 2021/05/01. DOI 10.1152/japplphysiol.00894.2020
Reply JACC: Cardiovascular Interventions, 2021/04. DOI 10.1016/j.jcin.2021.02.024
Sex and Race Differences in the Pathophysiology, Diagnosis, Treatment, and Outcomes of Valvular Heart Diseases Canadian Journal of Cardiology, 2021/02. DOI 10.1016/j.cjca.2021.02.003
Contrast-enhanced computed tomography assessment of aortic stenosis Heart, 2021/01/29. DOI 10.1136/heartjnl-2020-318556
Usefulness of the B-Type Natriuretic Peptides in Low Ejection Fraction, Low-Flow, Low-Gradient Aortic Stenosis Results from the TOPAS Multicenter Prospective Cohort Study Structural Heart, 2021. Annabi, M.-S., Zhang, B., Bergler-Klein, J., Dahou, A., Burwash, I.G., Guzzetti, E., Ong, G., Tastet, L., Orwat, S., Baumgartner, H., Bartko, P.E., Koschutnik, M., Mascherbauer, J., Mundigler, G., Cavalcante, J., Ribeiro, H.B., Rodès-Cabau, J., Pibarot, P., Clavel, M.-A.. DOI 10.1080/24748706.2021.1900630
The Canadian Women's Heart Health Alliance ATLAS on the Epidemiology, Diagnosis, and Management of Cardiovascular Disease in Women—Chapter 2: Scope of the Problem CJC Open, 2021. Jaffer, S., Foulds, H.J.A., Parry, M., Gonsalves, C.A., Pacheco, C., Clavel, M.-A., Mullen, K.A., Yip, C.Y.Y., Mulvagh, S.L., Norris, C.M.. DOI 10.1016/j.cjco.2020.10.009
Correlates of Coronary Artery Calcification Prevalence and Severity in Patients With Heterozygous Familial Hypercholesterolemia CJC Open, 2021. Drouin-Chartier, J.-P., Tremblay, A.J., Godbout, D., Gagnon, A., Clavel, M.-A., Clisson, M., Arsenault, B.J., Pibarot, P., Larose, É., Couture, P.. DOI 10.1016/j.cjco.2020.09.010
Comparison of Early Surgical or Transcatheter Aortic Valve Replacement Versus Conservative Management in Low-Flow, Low-Gradient Aortic Stenosis Using Inverse Probability of Treatment Weighting: Results From the TOPAS Prospective Observational Cohort Study. Journal of the American Heart Association, 2020/12/08. DOI 10.1161/jaha.120.017870
Multimodality Imaging for Discordant Low-Gradient Aortic Stenosis: Assessing the Valve and the Myocardium Frontiers in Cardiovascular Medicine, 2020/12/03. DOI 10.3389/fcvm.2020.570689
Impact of Left Ventricular Dysfunction in Patients with High and Low Gradient Severe Aortic Stenosis Following Transcatheter Aortic Valve Replacement. The Canadian journal of cardiology, 2020/11/05. DOI 10.1016/j.cjca.2020.10.014
Effect of Regional Upper Septal Hypertrophy on Echocardiographic Assessment of Left Ventricular Mass and Remodeling in Aortic Stenosis. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2020/10/14. DOI 10.1016/j.echo.2020.08.022
Measuring progression of aortic stenosis: computed tomography versus echocardiography. Heart (British Cardiac Society), 2020/10/09. DOI 10.1136/heartjnl-2020-317340
Structural Deterioration of Transcatheter Versus Surgical Aortic Valve Bioprostheses in the PARTNER-2 Trial. Journal of the American College of Cardiology, 2020/10/01. DOI 10.1016/j.jacc.2020.08.049
Pre- and Post-Operative Stroke Volume Impact After Surgical Aortic Valve Replacement for Severe Aortic Stenosis. Journal of the American College of Cardiology, 2020/10/01. DOI 10.1016/j.jacc.2020.08.060
Association of Bioprosthetic Aortic Valve Leaflet Calcification on Hemodynamic and Clinical Outcomes. Journal of the American College of Cardiology, 2020/10/01. DOI 10.1016/j.jacc.2020.08.034
Reclassification of prosthesis–patient mismatch after transcatheter aortic valve replacement using predicted vs. measured indexed effective orifice area European Heart Journal - Cardiovascular Imaging, 2020/09/30. DOI 10.1093/ehjci/jeaa235
Mixed Aortic Valve Disease: A Diagnostic Challenge, a Prognostic Threat Structural Heart, 2020/08/31. DOI 10.1080/24748706.2020.1817643
Sex-differences in echocardiographic assessment of aortic valve in young adult LDLr-/-/ApoB100/100/IGF-II+/- mice. Experimental gerontology, 2020/08/27. DOI 10.1016/j.exger.2020.111075
Balloon aortic valvuloplasty as a palliative treatment in patients with severe aortic stenosis and limited life expectancy: a single center experience. Aging, 2020/08/27. DOI 10.18632/aging.103862
Association of Natriuretic Peptide Levels After Transcatheter Aortic Valve Replacement With Subsequent Clinical Outcomes JAMA Cardiology, 2020/07/15. DOI 10.1001/jamacardio.2020.2614
Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans Heart, 2020/07/07. DOI 10.1136/heartjnl-2020-316722
Outcome of Flow-Gradient Patterns of Aortic Stenosis After Aortic Valve Replacement Circulation: Cardiovascular Interventions, 2020/07. DOI 10.1161/circinterventions.119.008792
Multiplanar “En Face” Reconstruction of the Aortic Valve JACC: Cardiovascular Imaging, 2020/07. DOI 10.1016/j.jcmg.2020.05.021
Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis JACC: Basic to Translational Science, 2020/07. DOI 10.1016/j.jacbts.2020.05.004
Estimation of Stroke Volume and Aortic Valve Area in Patients with Aortic Stenosis: A Comparison of Echocardiography versus Cardiovascular Magnetic Resonance. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2020/06/21. DOI 10.1016/j.echo.2020.03.020
Pathophysiology of Aortic Valve Calcification and Stenosis JACC: Cardiovascular Imaging, 2020/06. DOI 10.1016/j.jcmg.2020.04.024
Left Ventricular Hypertrophy and Clinical Outcomes Over 5 Years After TAVR JACC: Cardiovascular Interventions, 2020/06. DOI 10.1016/j.jcin.2020.03.011
Usefulness of the energy loss index in the adjudication of low-gradient aortic stenosis severity European Heart Journal - Cardiovascular Imaging, 2020/06/01. Ezequiel Guzzetti, Marie-Annick Clavel, Philippe Pibarot. DOI 10.1093/ehjci/jeaa052
Effect of bicuspid aortic valve phenotype on progression of aortic stenosis. European heart journal cardiovascular Imaging, 2020/05/09. DOI 10.1093/ehjci/jeaa068
Age, Sex, and Valve Phenotype Differences in Fibro-Calcific Remodeling of Calcified Aortic Valve. Journal of the American Heart Association, 2020/05/08. DOI 10.1161/jaha.119.015610
The right parasternal window: when Doppler-beam alignment may be life-saving in patients with aortic valve stenosis. Journal of cardiovascular medicine (Hagerstown, Md.), 2020/05/07. DOI 10.2459/jcm.0000000000000971
Regression of Left Ventricular Mass After Transcatheter Aortic Valve Replacement: The PARTNER Trials and Registries. Journal of the American College of Cardiology, 2020/05/01. DOI 10.1016/j.jacc.2020.03.042
Transvalvular Flow, Sex, and Survival After Valve Replacement Surgery in Patients With Severe Aortic Stenosis. Journal of the American College of Cardiology, 2020/04/01. DOI 10.1016/j.jacc.2020.02.065
Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide in Elderly Patients With Valvular Heart Disease. Journal of the American College of Cardiology, 2020/04/01. DOI 10.1016/j.jacc.2020.02.031
Discordant Echocardiographic Grading in Low Gradient Aortic Stenosis (DEGAS Study) From the Italian Society of Echocardiography and Cardiovascular Imaging Research Network: Rationale and Study Design. Journal of cardiovascular echography, 2020/04/01. DOI 10.4103/jcecho.jcecho_68_20
Bone Mineral Density and Progression Rate of Calcific Aortic Valve Stenosis. Journal of the American College of Cardiology, 2020/04/01. DOI 10.1016/j.jacc.2020.01.053
Sex-Related Differences in the Extent of Myocardial Fibrosis in Patients With Aortic Valve Stenosis. JACC. Cardiovascular imaging, 2020/03/13. DOI 10.1016/j.jcmg.2019.06.014
True-Severe or Pseudo-Severe AS? 2020/03/09.
Characteristics and usefulness of unintended premature ventricular contraction during invasive assessment of aortic stenosis. International journal of cardiology, 2020/02/28. DOI 10.1016/j.ijcard.2020.02.053
State of the Science in Women's Cardiovascular Disease: A Canadian Perspective on the Influence of Sex and Gender. Journal of the American Heart Association, 2020/02/17. DOI 10.1161/jaha.119.015634
Mitral Regurgitation in Low-Flow, Low-Gradient Aortic Stenosis Patients Undergoing TAVR: Insights From the TOPAS-TAVI Registry. JACC. Cardiovascular interventions, 2020/02/12. DOI 10.1016/j.jcin.2019.11.042
Sex Differences in the Pathophysiology, Diagnosis, and Management of Aortic Stenosis. Cardiology clinics, 2020/02/01. DOI 10.1016/j.ccl.2019.09.008
Low and elevated B-type natriuretic peptide levels are associated with increased mortality in patients with preserved ejection fraction undergoing transcatheter aortic valve replacement: an analysis of the PARTNER II trial and registry. European heart journal, 2020/02/01. DOI 10.1093/eurheartj/ehz892
Biomarkers Associated with Aortic Stenosis and Structural Bioprosthesis Dysfunction. Cardiology clinics, 2020/02/01. DOI 10.1016/j.ccl.2019.09.005
Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction. Journal of the American College of Cardiology, 2020/02/01. DOI 10.1016/j.jacc.2019.11.039
Assessment of Aortic Stenosis Severity: A Multimodality Approach. Cardiology clinics, 2020/02/01. DOI 10.1016/j.ccl.2019.09.004
A Decade of Revolutions in Calcific Aortic Stenosis. Cardiology clinics, 2020/02/01. DOI 10.1016/j.ccl.2019.10.001
Airway smooth muscle adapting in dynamic conditions is refractory to the bronchodilator effect of a deep inspiration. American journal of physiology. Lung cellular and molecular physiology, 2020/01/08. DOI 10.1152/ajplung.00270.2019
Calcific Aortic Valve Stenosis and Atherosclerotic Calcification. Current atherosclerosis reports, 2020/01/07. DOI 10.1007/s11883-020-0821-7
Immediate Outcomes of Aortic Valve Neocuspidization with Glutaraldehyde-treated Autologous Pericardium: a Multicenter Study Brazilian Journal of Cardiovascular Surgery, 2020. DOI 10.21470/1678-9741-2020-0019
Aortic Stenosis and Cardiac Amyloidosis: Watch Out for Traps! JACC: Case Reports, 2020. Ternacle, J., Pibarot, P., Clavel, M.-A.. DOI 10.1016/j.jaccas.2020.10.011
Aortic Stenosis Heart Valve Disease - State of the Art, 2020. DOI 10.1007/978-3-030-23104-0_3
Study Design of the Prospective Non-Randomized Single-Arm Multicenter Evaluation of the Durability of Aortic Bioprosthetic Valves with RESILIA Tissue in Subjects under 65 Years Old (RESILIENCE Trial) Structural Heart, 2020/01. Philippe Pibarot, Michael A. Borger, Marie-Annick Clavel, Bartley Griffith, Joseph E. Bavaria, Lars G. Svensson, Vinod H. Thourani. DOI 10.1080/24748706.2019.1686554
Importance of Flow in Risk Stratification of Aortic Stenosis Canadian Journal of Cardiology, 2020/01. Ezequiel Guzzetti, Marie-Annick Clavel, Philippe Pibarot. DOI 10.1016/j.cjca.2019.10.020
Extracellular Myocardial Volume in Patients With Aortic Stenosis. Journal of the American College of Cardiology, 2020/01/01. DOI 10.1016/j.jacc.2019.11.032
Aortic Valve disease, An Issue of Cardiology Clinics Marie-Annick Clavel, Philippe Pibarot, 2019/11/27.
Early Aortic Valve Replacement versus Watchful Waiting in Asymptomatic Severe Aortic Stenosis: A Study-Level Meta-Analysis Structural Heart, 2019/11. Michel Pompeu B.O. Sá, Luiz Rafael P. Cavalcanti, Antônio C.A. Escorel Neto, Álvaro M. Perazzo, Matheus Simonato, Marie-Annick Clavel, Philippe Pibarot, Ricardo C. Lima. DOI 10.1080/24748706.2019.1652946
Aortic Stenosis and Cardiac Amyloidosis: JACC Review Topic of the Week. Journal of the American College of Cardiology, 2019/11/01. DOI 10.1016/j.jacc.2019.09.056
Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis. Circulation. Genomic and precision medicine, 2019/10/15. DOI 10.1161/circgen.119.002617
Normal-flow low-gradient severe aortic stenosis is a frequent and real entity. European heart journal cardiovascular Imaging, 2019/10/01. DOI 10.1093/ehjci/jez211
Shortening of airway smooth muscle is modulated by prolonging the time without simulated deep inspirations in ovine tracheal strips. Journal of applied physiology (Bethesda, Md. : 1985), 2019/09/23. DOI 10.1152/japplphysiol.00423.2019
Discordant Grading of Aortic Stenosis Severity: New Insights from an In Vitro Study Structural Heart, 2019/09. Jérôme Adda, Viktoria Stanova, Anne-Sophie Zenses, Marie-Annick Clavel, Paul Barragan, Guillaume Penaranda, Gilbert Habib, Philippe Pibarot, Régis Rieu. DOI 10.1080/24748706.2019.1632507
Why and How to Measure Aortic Valve Calcification in Patients With Aortic Stenosis. JACC. Cardiovascular imaging, 2019/09/01. DOI 10.1016/j.jcmg.2019.01.045
Surgical aortic valve replacement and patient-prosthesis mismatch: a meta-analysis of 108 182 patients. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2019/07/01. DOI 10.1093/ejcts/ezy466
Staging Cardiac Damage in Patients With Asymptomatic Aortic Valve Stenosis. Journal of the American College of Cardiology, 2019/07/01. DOI 10.1016/j.jacc.2019.04.065
Impact of surgical aortic root enlargement on the outcomes of aortic valve replacement: a meta-analysis of 13 174 patients. Interactive cardiovascular and thoracic surgery, 2019/07/01. DOI 10.1093/icvts/ivy364
Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification. JAMA cardiology, 2019/07/01. DOI 10.1001/jamacardio.2019.1581
Chronic Kidney Disease and the Pathophysiology of Valvular Heart Disease. The Canadian journal of cardiology, 2019/05/28. DOI 10.1016/j.cjca.2019.05.028
Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography. CJC open, 2019/04/12. DOI 10.1016/j.cjco.2019.03.004
Oral Anticoagulation Therapy and Progression of Calcific Aortic Valve Stenosis. Journal of the American College of Cardiology, 2019/04/01. DOI 10.1016/j.jacc.2019.01.043
Prosthesis-Patient Mismatch Negatively Affects Outcomes after Mitral Valve Replacement: Meta-Analysis of 10,239 Patients. Brazilian journal of cardiovascular surgery, 2019/03/01. DOI 10.21470/1678-9741-2019-0069
Dobutamine Stress Echocardiography in Low-Flow, Low-Gradient Aortic Stenosis: Flow Reserve Does Not Matter Anymore. Journal of the American Heart Association, 2019/03/01. DOI 10.1161/JAHA.119.012212
Biomarkers of aortic bioprosthetic valve structural degeneration. Current opinion in cardiology, 2019/03/01. DOI 10.1097/hco.0000000000000590
Imaging and Impact of Myocardial Fibrosis in Aortic Stenosis. JACC. Cardiovascular imaging, 2019/02/01. DOI 10.1016/j.jcmg.2018.11.026
How Do We Reconcile Echocardiography, Computed Tomography, and Hybrid Imaging in Assessing Discordant Grading of Aortic Stenosis Severity? JACC. Cardiovascular imaging, 2019/02/01. DOI 10.1016/j.jcmg.2018.11.027
Aortic stenosis: what is the role of aging processes? Aging, 2019/02/01. DOI 10.18632/aging.101826
Prosthetic Aortic Valve Encyclopedia of Biomedical Engineering, 2019. DOI 10.1016/B978-0-12-801238-3.11103-1
Functional and Morphological Interplay of the Aortic Valve, the Aortic Root and the Left Ventricule Surgical Management of Aortic Pathologies, 2019. DOI 10.1007/978-3-7091-4874-7_6
The Role of Imaging in Measuring Disease Progression and Assessing Novel Therapies in Aortic Stenosis. JACC. Cardiovascular imaging, 2019/01/01. DOI 10.1016/j.jcmg.2018.10.023
Sex-Related Differences in Low-Gradient, Low-Ejection Fraction Aortic Stenosis: Results From the Multicenter TOPAS Study. JACC. Cardiovascular imaging, 2019/01/01. DOI 10.1016/j.jcmg.2018.11.003
Outcomes From Transcatheter Aortic Valve Replacement in Patients With Low-Flow, Low-Gradient Aortic Stenosis and Left Ventricular Ejection Fraction Less Than 30%: A Substudy From the TOPAS-TAVI Registry. JAMA cardiology, 2019/01/01. DOI 10.1001/jamacardio.2018.4320
Long-Term Implications of Atrial Fibrillation in Patients With Degenerative Mitral Regurgitation. Journal of the American College of Cardiology, 2019/01/01. DOI 10.1016/j.jacc.2018.10.067
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